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Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants

  • 176 points
  • 10 days ago

  • @leephillips
  • Created a post

Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants


@trenchgun 9 days

Replying to @leephillips 🎙

https://xkcd.com/1217/

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@zbjornson 10 days

Replying to @leephillips 🎙

They're showing inhibition at 100 ug/ml, but it looks like high doses result in serum CBDA concentrations in the low 100s of ng/ml [1].

[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498943/

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@hammock 10 days

Replying to @leephillips 🎙

Too many "promising" studies like cannabis, vitamin D, chloroquine, ivermectin, etc have been later fact-checked by the CDC as bad science, to rely on anything but the CDC's word (or Fauci). Until the CDC says so I won't believe it. Right now it seems like mass vaccination is our only way out of this pandemic and back to normal.

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@oxymoran 10 days

Replying to @leephillips 🎙

Anecdote: Wife has had very mild covid for 5-6 days now. Been sharing a bong with her and I have no symptoms. I smoke much more than she does. She is boosted. I stopped after the second dose.

Also, I heard somewhere, and I forget where now, that hot smoke could play a role in this, but this study seemed to indicate it was orally bioactive as well. I would assume the in-vivo test wasn’t blowing hot smoke in a test tube but rather bathing in a cannabinoid solution?

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@bitxbitxbitcoin 10 days

Replying to @leephillips 🎙

Note that they are talking about CBGa and CBDa. While these are present in whole flower and some concentrates, heating it up for vaporization or combustion leads to decarboxylation meaning you’ll be ingesting CBD and CBG.

Can’t wait for more research. Anyone wanting to act on this should go for non baked edibles such as tinctures.

Since 2018, a lot of these products are actually legally available online in most of the States.

Check the Certificate of Authenticity to see the tested levels of CBDa and CBGa.

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@CheatModeON 10 days

Replying to @leephillips 🎙

Now South Park makes sense.

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@mountainriver 10 days

Replying to @leephillips 🎙

Totally anecdotal but my girlfriend and I recently went to wedding and even with pre testing and everyone vaccinated, a lot of people got Covid.

I was super high that night (as most nights) and walked away unscathed. Obviously this could be due to a lot of things but that hasn’t stopped me from rubbing it in all my friends faces.

It’s been of the few times in my life where my weed habit looks smart, and I’m loving every minute of it.

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@drno123 9 days

Replying to @leephillips 🎙

Cannabis mandates now!

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@jonnycomputer 10 days

Replying to @leephillips 🎙

I did't know anything about the journal. I must admit, that something titled "Journal of Natural Products" didn't inspire much confidence. But it does look like it has been around for quite a long while, and has a respectable impact factor for a specialized journal too.

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@sonofhans 10 days

Replying to @leephillips 🎙

This reminds me of William S Burrough’s “Cities of the Red Night,” in which a deadly plague appears suddenly. The character Dr. Pierson is a heroin addict, and helps discover that heroin is prophylactic against the fever:

“A top government official bluntly warned: ‘Virus B-23 now loose in our overcrowded cities, is an agent that produces biologic changes in those affected – fatal in many cases, permanent and hereditary in those who survive and become carriers for that strain, which as a matter of survival they will spread as far and fast as possible to destroy enemies and quite literally make friends.’ Junkies, however, are only lightly affected by the virus and remain characteristically unchanged.

“He recovers in the fear because of his addiction, and the word went out that the junk was the only insurance against the fever. No stemming the black market the Government concedes and legalises. Now begins a deadly war to extermination between the junkies and the fever-freaks.”

https://en.wikipedia.org/wiki/Cities_of_the_Red_Night

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@knuthsat 9 days

Replying to @leephillips 🎙

Any idea if amount of cannabinoids produced by our own body is high enough?

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@mettamage 9 days

Replying to @leephillips 🎙

Note that [1]

> Even when smoked, THCA-A is only partially transformed to THC. The conversion rates during smoking range from a maximum of 70% under optimized analytical conditions (temperatures higher than 140°C) to simulated smoking processes, where only 30% of the spiked THCA-A was recovered as THC.

[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549534/

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@tommek4077 9 days

Replying to @leephillips 🎙

Too much to read dude, should I get stoned now or not?

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@fghorow 10 days

Replying to @leephillips 🎙

I sense a new startup opportunity: Pizza-as-a-Service.

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@sAbakumoff 9 days

Replying to @leephillips 🎙

Good idea. Right-wing lunatics, QAnaon believers, anti-vax crusaders should get high and fcking relax already.

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@tedivm 10 days

Replying to @leephillips 🎙

It's important to note that the chemicals they tested with were the cannabinoid acids (CBDA, THCA). When smoking or cooking those acids are converted via decarboxylation. These final chemicals were not part of this study.

In other words, this study only tested people eating raw uncooked cannabis. It does not tell you much about whether any benefits will be provided to your average smoker.

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@smm11 9 days

Replying to @leephillips 🎙

It might be even simpler - reducing inflammation lessens the effects of Covid.

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@aleksandarbos 9 days

Replying to @leephillips 🎙



@AzzieElbab 10 days

Replying to @leephillips 🎙

Oh yeah? Why are there any infections at all in British Columbia?

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@xer0x 10 days

Replying to @leephillips 🎙

I've been ignoring the weed freaks spouting off about this. Great to see they were talking about something sorta science based at least.

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@stadium 10 days

Replying to @leephillips 🎙

"Our infection inhibition assay results clearly indicate that CBDA and CBGA are both able to block cell entry by SARS-CoV-2. The concentrations needed to block infection by 50% of viruses is high but might be clinically achievable. For example, CBDA administered orally to human volunteers at 0.063 mg/kg showed greater bioavailability than CBD and produced maximum plasma concentrations of 0.21 μM. (32) In beagle dogs, oral administration of CBDA at 1 mg/kg was well tolerated, was 2-fold more bioavailable than CBD, and produced serum levels up to 1.42 μM. (41) Although no data on the bioavailability of CBGA are yet available, the data for CBDA suggest that μM plasma and serum concentrations for CBGA should also be possible."

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@lgats 9 days

Replying to @leephillips 🎙

see also, Cannabidiol Inhibits SARS-CoV-2 Replication and Promotes the Host Innate Immune Response

Preprint. 2021 Mar 10.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987002/

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@doingtheiroming 9 days

Replying to @leephillips 🎙

Surprisingly high number of happily married stoners in here.

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@onychomys 10 days

Replying to @leephillips 🎙



@fer 10 days

Replying to @leephillips 🎙



@gpcr1949 9 days

Replying to @leephillips 🎙

The IC50(reported as 24 μg/mL for CBDA against wild type in the live virus assay or 76 μM in more typical units) is far too high to have a relevant effect, you would probably have to use infeasibly large amounts of hemp products (orders of magnitude higher ones). I would not count on cannabinoids to help with preventing or treating sars-cov-2 infections. I expect some pushback against this result in a few days.

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