That would be great! Mind shooting me an email at email@example.com?
Recent @mattangriffel Activity
That would be great! Mind shooting me an email at firstname.lastname@example.org?
Thanks for the tip, would love to chat further if you want to shoot me an email at email@example.com
Wow. That's beautiful, thanks for sharing.
Wow this is great. No I hadn't seen this but I'll definitely be reaching out to him. Thanks!
Appreciate these thoughts talolard. I like the idea of partnering with local governments and non-profits, and would welcome any introductions or suggestions there. As you mentioned, most would want to see efficacy in a few pilot regions first, which is what we're currently working on.
While there are some regulations (both state and federal) around what we can and can't say publicly, most of our obstacles so far have been the policies of sites like Facebook, Google, Reddit and the like. Many of them have gotten into trouble before with scammy rehab programs preying on vulnerable populations, so they've made it incredibly difficult for startups like us who have something new to offer to even get the word out. We're working on it, but it's still hard.
I agree with you about getting the word out in a grassroots way, and we've definitely been to some of the hardest-hit areas out there. The problem is that 80% of opioid users aren't currently seeking treatment and are just like you and me, but living with a secret problem. Those are the people we want to reach and let them know there are options for them.
Facebook and Google both require LegitScript (https://legitscript.com/) certification. We're in the process of going through that and we're told it may take several months.
Oof, where to begin. There are regulations around what states we're allowed to operate in, what kinds of clinicians are able to see patients, how we have to treat patient data, and what the clinical protocols have to look like.
In terms of regulations restricting what we can say publicly, besides FDA regulations around medical claims we're allowed to make, our biggest obstacle is that many of the common channels available to startups for building awareness are restricted or blocked entirely. Facebook and Google, for example, both require LegitScript (https://legitscript.com/) certification. We're in the process of going through that and it may take several months. That's also a requirement for us to be able to do payment processing through services like Stripe, since we qualify as a "high-risk business" since we do both telemedicine and addiction-recovery services.
But even when we do have those certifications, Google, Facebook, Reddit, and many other sites have a blanket ban against targeting users who are part of addiction and addiction-recovery groups.
It's not that we can't comply with any of these regulations (and in fact, we're working on many of them as we speak), but many of them are really onerous and time consuming for a startup given the stage that we're at.
We're primarily focused on medication-assisted treatment with Suboxone. Sorry to hear about your experience irscott, it's certainly not the right solution for everyone.
Fixed! Thanks for catching that Brian.
Yes! MAPS has conducted and collected some really great research around psychedelics and their use in the treatment of things like PTSD and addiction. Specifically, Ibogaine Therapy has shown some real promise around drug addiction .
Unfortunately, it's going to be quite a while before any psychedelics are FDA-approved. Right now, MDMA and Psilocybin are both in FDA trials (Phase 3 and Phase 2, respectively) but I think Ibogaine is still quite a ways out.
Interestingly, in terms of your comment about Ibogaine's use outside of the US: other countries besides the US (and Canada) have not really seen quite the same problem in terms of opioid addiction as we have here in the US. This is mostly due to American pharmaceutical companies historically having been really successful at convincing US doctors to prescribe opioid-based pain medication , and due to the fact that pain was added as a 5th vital sign in 2001 by the Joint Commission . That isn't to say that other countries haven't had problems with opioid addiction, but it hasn't generally been at nearly the scale of the problem in the US, and other countries have had varying rates of success with solutions that haven't been possible in the US thus far.
 There's a really great John Oliver segment about this https://www.youtube.com/watch?v=-qCKR6wy94U
Mattan here (co-founder of Ophelia). We're certainly considering any options that are scientifically backed and evidence-based. Medication-Assisted Treatment (MAT) is the standard in the medical community among addiction specialists and it's proven to be the most effective solution.
Kratom is certainly one of the solutions that people trying to overcome opioid addiction are resorting to, but it's unclear whether it's effective — not enough studies have been performed, and it's not an FDA-approved treatment for opioid use disorder. There's also some evidence to suggest that kratom actually leads to more health problems than it solves .
As someone who teaches coding to beginners for a living (I founded One Month and I teach Python to business students at Columbia University), this language looks really intimidating to beginners.
Maybe Pyret isn't for beginners, and it's intended to teach people who already have some basic knowledge more advanced concepts like functional programming. That's fine.
But to a total beginner, the syntax of Pyret is definitely a step back in terms of readability.
In what world is:
...easier for a beginner to understand than:
fun square(n :: Number) -> Number: n * n end
I get that the intention of this language seems to be to help beginners avoid some of the more common pitfalls that they may run into (ex. unexpected parameters and return values), but it seems like they do it at the expense of the total beginner's ability to understand and keep track of lots of new concepts when they're just starting out.
def square(n): return n * n
No, it's a way of dealing with the issue of deadlocked decisions between co-founders if equity is split evenly.
Usually in the case of a deadlocked decision between co-founders, you can resort to a board vote, after which you resort to a vote among shareholders.
If, say, two co-founders split equity and they're both on the board, then a disagreement could lead to a problem. If, however, only one of them (usually the CEO) is on the board, then there's no deadlock there.
Sometimes people recommend giving one co-founder (again, usually the CEO) one extra share so their vote can break a deadlock. But putting only the CEO on a board is another way to deal with that problem without having to worry about extra shares.
Digital – every button on the page says "Buy Digital Book Now"
Ask HN: Do you primarily use Python 2 or 3?
2 points • 3 comments
Yeah, but also this is nothing new.
In a recent Planet Money episode (#688: Brilliant vs. Boring), they talk about how when John Bogle first introduced the index mutual fund in 1975, it got a lot of criticism (and not much adoption) with people claiming that they were "un-american" and "Bogle's folly".
It's possible that there's some sort of concentrated media push going on here, but the story hasn't changed much in the last 40 years. And I would hope that if people with a lot of money were trying to smear index funds, they'd at least come up with a new angle.
> The only way to change culture is through law.
Not true. What about education?
Change `alpha` to `beta1` to prep for release of Rails 5
1 points • 0 comments
Show HN: JobSignal – 20k postings from AngelList analyzed
13 points • 3 comments